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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50099788
Substrate
n/a
Meas. Tech.
ChEMBL_62018 (CHEMBL671639)
IC50
20300±n/a nM
Citation
 Cabedo, N; Andreu, I; Ramírez De Arellano, MC; Chagraoui, A; Serrano, A; Bermejo, A; Protais, P; Cortes, D Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines. J Med Chem 44:1794-801 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50099788
Synonyms:
5-Benzyl-6-propyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline | CHEMBL53520
Type:
Small organic molecule
Emp. Form.:
C20H23NO2
Mol. Mass.:
309.4021
SMILES:
CCCN1CCc2cc3OCOc3cc2[C@@H]1Cc1ccccc1
Structure:
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