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Target
Ribosomal protein S6 kinase beta-1
Ligand
BDBM50543601
Substrate
n/a
Meas. Tech.
ChEMBL_1989570 (CHEMBL4623305)
Ki
20±n/a nM
Citation
 Chen, Y; Li, Q; Li, Q; Xing, S; Liu, Y; Liu, Y; Chen, Y; Liu, W; Feng, F; Sun, H p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. J Med Chem 63:10135-10157 (2020) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM50543601
Synonyms:
CHEMBL2134202
Type:
Small organic molecule
Emp. Form.:
C19H21F3N6
Mol. Mass.:
390.4054
SMILES:
CCc1cncnc1N1CCN(Cc2nc3cc(ccc3[nH]2)C(F)(F)F)CC1
Structure:
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