Reaction Details Report a problem with these data
Target
Somatostatin receptor type 1
Ligand
BDBM50100745
Substrate
n/a
Meas. Tech.
ChEMBL_200539 (CHEMBL805043)
IC50
17.1±n/a nM
Citation
 Rivier, JE; Hoeger, C; Erchegyi, J; Gulyas, J; DeBoard, R; Craig, AG; Koerber, SC; Wenger, S; Waser, B; Schaer, JC; Reubi, JC Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem 44:2238-46 (2001) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 1
Synonyms:
SOMATOSTATIN SST1 | SRIF-2 | SS-1-R | SS1-R | SS1R | SSR1_HUMAN | SSTR1 | Somatostatin receptor type 1 (SSTR1)
Type:
Enzyme
Mol. Mass.:
42692.81
Organism:
Homo sapiens (Human)
Description:
P30872
Residue:
391
Sequence:
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
  
Inhibitor
Name:
BDBM50100745
Synonyms:
CHEMBL436887 | Des-AA1,2,5-[DTrp8,IAmp9,Tyr11]-SRIF | Des-AA1,2,5-[IAmp9,Tyr11]-SRIF
Type:
Small organic molecule
Emp. Form.:
C74H96N14O16S2
Mol. Mass.:
1501.768
SMILES:
CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Structure:
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