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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50544111
Substrate
n/a
Meas. Tech.
ChEMBL_1991674 (CHEMBL4625409)
Ki
800±n/a nM
Citation
 de Souza, ACA; Mori, M; Sens, L; Rocha, RF; Tizziani, T; de Souza, LFS; Domeneghini Chiaradia-Delatorre, L; Botta, M; Nunes, RJ; Terenzi, H; Menegatti, ACO A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50544111
Synonyms:
CHEMBL4638054
Type:
Small organic molecule
Emp. Form.:
C16H11NO5
Mol. Mass.:
297.2622
SMILES:
OC(=O)c1ccc(\C=C\C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Structure:
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