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Target
Histone-lysine N-methyltransferase SETD7
Ligand
BDBM50545364
Substrate
n/a
Meas. Tech.
ChEMBL_1994888 (CHEMBL4628783)
IC50
23000±n/a nM
Citation
 Hou, Z; Min, W; Zhang, R; Niu, A; Li, Y; Cao, L; Han, J; Luo, C; Yang, P; Ding, H Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SETD7
Synonyms:
Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN
Type:
Enzyme
Mol. Mass.:
40691.12
Organism:
Homo sapiens (Human)
Description:
Q8WTS6
Residue:
366
Sequence:
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
  
Inhibitor
Name:
BDBM50545364
Synonyms:
CHEMBL4639453
Type:
Small organic molecule
Emp. Form.:
C18H18N2O5S
Mol. Mass.:
374.411
SMILES:
CS(=O)(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C1=CC(=O)C=CC1=O |c:24,t:20|
Structure:
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