Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50103700
Substrate
n/a
Meas. Tech.
ChEBML_140799
IC50
10±n/a nM
Citation
 Kordik, CP; Luo, C; Zanoni, BC; Dax, SL; McNally, JJ; Lovenberg, TW; Wilson, SJ; Reitz, AB Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor. Bioorg Med Chem Lett 11:2283-6 (2001) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50103700
Synonyms:
CHEMBL3084801 | N-{4-[5-Amino-1-(4-trifluoromethyl-phenyl)-1H-pyrazol-3-yl]-cyclohexylmethyl}-2-nitro-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H24F3N5O4S
Mol. Mass.:
523.528
SMILES:
Nc1cc(nn1-c1ccc(cc1)C(F)(F)F)C1CCC(CNS(=O)(=O)c2ccccc2[N+]([O-])=O)CC1 |(-4.59,.2,;-3.68,1.44,;-2.14,1.44,;-1.67,2.91,;-2.91,3.81,;-4.16,2.91,;-5.61,3.39,;-6.75,2.35,;-8.22,2.82,;-8.54,4.35,;-7.4,5.36,;-5.93,4.88,;-10.01,4.82,;-10.59,6.31,;-11.33,3.93,;-11.32,5.23,;-.2,3.39,;.12,4.89,;1.59,5.36,;2.73,4.33,;4.19,4.79,;5.32,3.77,;6.79,4.23,;7.11,5.72,;8.28,4.63,;7.93,3.19,;7.6,1.69,;8.74,.67,;10.2,1.13,;10.53,2.63,;9.39,3.67,;9.7,5.16,;11.16,5.64,;8.56,6.21,;2.4,2.82,;.94,2.35,)|
Structure:
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