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Target
Potassium channel subfamily K member 10
Ligand
BDBM50546004
Substrate
n/a
Meas. Tech.
ChEMBL_2013745 (CHEMBL4667323)
EC50
5500±n/a nM
Citation
 Iwaki, Y; Yashiro, K; Kokubo, M; Mori, T; Wieting, JM; McGowan, KM; Bridges, TM; Engers, DW; Denton, JS; Kurata, H; Lindsley, CW Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett 29:1601-1604 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 10
Synonyms:
KCNK10 | KCNKA_HUMAN | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | TREK2
Type:
PROTEIN
Mol. Mass.:
59774.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105637
Residue:
538
Sequence:
MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
  
Inhibitor
Name:
BDBM50546004
Synonyms:
CHEMBL4759521
Type:
Small organic molecule
Emp. Form.:
C15H8BrF4NO3S
Mol. Mass.:
438.192
SMILES:
OC(=O)c1cc(Br)c(F)cc1NC(=O)c1ccc(SC(F)(F)F)cc1
Structure:
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