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Target
Complement factor D
Ligand
BDBM50546245
Substrate
n/a
Meas. Tech.
ChEMBL_2015002 (CHEMBL4668580)
Kd
>30000±n/a nM
Citation
 Cheng, KJ; Hsieh, CM; Nepali, K; Liou, JP Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye. J Med Chem 63:10533-10593 (2020) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50546245
Synonyms:
CHEMBL4101312
Type:
Small organic molecule
Emp. Form.:
C16H14N2O2
Mol. Mass.:
266.2946
SMILES:
NC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Structure:
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