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Target
Phospholipid hydroperoxide glutathione peroxidase
Ligand
BDBM50547207
Substrate
n/a
Meas. Tech.
ChEMBL_2017294 (CHEMBL4670872)
EC50
>33000±n/a nM
Citation
 Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Phospholipid hydroperoxide glutathione peroxidase
Synonyms:
1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx
Type:
PROTEIN
Mol. Mass.:
22031.99
Organism:
Homo sapiens
Description:
ChEMBL_117999
Residue:
196
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
  
Inhibitor
Name:
BDBM50547207
Synonyms:
CHEMBL4781953
Type:
Small organic molecule
Emp. Form.:
C33H41ClN2O3SSi
Mol. Mass.:
609.294
SMILES:
[#6]-[#8]-c1ccc(cc1Cl)-[#7](-[#6](-[#6](=O)-[#7]-[#6]-[#6]-c1ccccc1)-c1cccs1)-[#6](=O)C#C[Si;v4]([#6](-[#6])-[#6])([#6](-[#6])-[#6])[#6](-[#6])-[#6]
Structure:
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