Reaction Details Report a problem with these data
Target
Phospholipid hydroperoxide glutathione peroxidase
Ligand
BDBM50547209
Substrate
n/a
Meas. Tech.
ChEMBL_2017294 (CHEMBL4670872)
EC50
1200±n/a nM
Citation
 Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Phospholipid hydroperoxide glutathione peroxidase
Synonyms:
1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx
Type:
PROTEIN
Mol. Mass.:
22031.99
Organism:
Homo sapiens
Description:
ChEMBL_117999
Residue:
196
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
  
Inhibitor
Name:
BDBM50547209
Synonyms:
CHEMBL4779501
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N2O
Mol. Mass.:
373.276
SMILES:
Clc1ccc(cc1)C(N1CCN(CC1)C(=O)C#C)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: