Reaction Details Report a problem with these data
Target
Phospholipid hydroperoxide glutathione peroxidase
Ligand
BDBM50547210
Substrate
n/a
Meas. Tech.
ChEMBL_2017294 (CHEMBL4670872)
EC50
1800±n/a nM
Citation
 Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Phospholipid hydroperoxide glutathione peroxidase
Synonyms:
1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx
Type:
PROTEIN
Mol. Mass.:
22031.99
Organism:
Homo sapiens
Description:
ChEMBL_117999
Residue:
196
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
  
Inhibitor
Name:
BDBM50547210
Synonyms:
CHEMBL4765119
Type:
Small organic molecule
Emp. Form.:
C23H26Cl2N2OSi
Mol. Mass.:
445.457
SMILES:
[#6][Si;v4]([#6])([#6])C#C[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Structure:
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