Reaction Details Report a problem with these data
Target
Phospholipid hydroperoxide glutathione peroxidase
Ligand
BDBM50547215
Substrate
n/a
Meas. Tech.
ChEMBL_2017294 (CHEMBL4670872)
EC50
22000±n/a nM
Citation
 Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Phospholipid hydroperoxide glutathione peroxidase
Synonyms:
1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx
Type:
PROTEIN
Mol. Mass.:
22031.99
Organism:
Homo sapiens
Description:
ChEMBL_117999
Residue:
196
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
  
Inhibitor
Name:
BDBM50547215
Synonyms:
CHEMBL4758630
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N3O
Mol. Mass.:
414.328
SMILES:
C\C=C(/C#N)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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