Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50547499
Substrate
n/a
Meas. Tech.
ChEMBL_2018482 (CHEMBL4672060)
Kd
6860±n/a nM
Citation
 Cirillo, PF; Asojo, OA; Khire, U; Lee, Y; Mootien, S; Hegan, P; Sutherland, AG; Peterson-Roth, E; Ledizet, M; Koski, RA; Anthony, KG Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders. ACS Med Chem Lett 11:1843-1847 (2020) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50547499
Synonyms:
CHEMBL4785454
Type:
Small organic molecule
Emp. Form.:
C28H25N5O8S2
Mol. Mass.:
623.657
SMILES:
CC(C)C(=O)c1c(Cc2cccc(c2)\N=N\c2ccc3c(cc(c(N)c3c2O)S(O)(=O)=O)S(O)(=O)=O)nn2ccccc12
Structure:
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