Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50106238
Substrate
n/a
Meas. Tech.
ChEMBL_48457 (CHEMBL662862)
Ki
5500±n/a nM
Citation
 Mackman, RL; Katz, BA; Breitenbucher, JG; Hui, HC; Verner, E; Luong, C; Liu, L; Sprengeler, PA Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator. J Med Chem 44:3856-71 (2001) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50106238
Synonyms:
4-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine | CHEMBL125153
Type:
Small organic molecule
Emp. Form.:
C21H16ClN3O
Mol. Mass.:
361.824
SMILES:
NC(=N)c1ccc2[nH]c(cc2c1Cl)-c1cccc(-c2ccccc2)c1O
Structure:
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