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Target
Glutamate carboxypeptidase 2
Ligand
BDBM50085699
Substrate
n/a
Meas. Tech.
ChEMBL_141138 (CHEMBL749038)
IC50
0.5±n/a nM
Citation
 Jackson, PF; Tays, KL; Maclin, KM; Ko, YS; Li, W; Vitharana, D; Tsukamoto, T; Stoermer, D; Lu, XC; Wozniak, K; Slusher, BS Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. J Med Chem 44:4170-5 (2001) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1
Type:
PROTEIN
Mol. Mass.:
84547.28
Organism:
Rattus norvegicus
Description:
ChEMBL_68365
Residue:
752
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
  
Inhibitor
Name:
BDBM50085699
Synonyms:
(S,S / R,R)4-Carboxy-5-[(2,4-dicarboxy-butyl)-hydroxy-phosphinoyl]-pentanoic acid | (meso)4-Carboxy-5-[(2,4-dicarboxy-butyl)-hydroxy-phosphinoyl]-pentanoic acid | 2-[(2,4-Dicarboxy-butyl)-hydroxy-phosphinoylmethyl]-pentanedioic acid | 4-Carboxy-5-[(2,4-dicarboxy-butyl)-hydroxy-phosphinoyl]-pentanoic acid | CHEMBL134749
Type:
Small organic molecule
Emp. Form.:
C12H19O10P
Mol. Mass.:
354.247
SMILES:
OC(=O)CCC(CP(O)(=O)CC(CCC(O)=O)C(O)=O)C(O)=O
Structure:
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