Reaction Details
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Mitogen-activated protein kinase 15
Ligand
BDBM50548060
Substrate
n/a
Meas. Tech.
ChEMBL_2019828 (CHEMBL4673641)
IC50
110±n/a nM
Citation
Thomas, MG; De Rycker, M; Ajakane, M; Crouch, SD; Campbell, L; Daugan, A; Fra, G; Guerrero, C; Mackenzie, CJ; MacLean, L; Manthri, S; Martin, F; Norval, S; Osuna-Cabello, M; Riley, J; Shishikura, Y; Miguel-Siles, J; Simeons, FRC; Stojanovski, L; Thomas, J; Thompson, S; Velasco, RF; Fiandor, JM; Wyatt, PG; Read, KD; Gilbert, IH; Miles, TJ Identification of 6-amino-1 RSC Med Chem 11:1168-1177 (2020) [PubMed] Article More Info.:
Target
Name:
Mitogen-activated protein kinase 15
Synonyms:
ERK-8 | ERK7 | ERK8 | Extracellular signal-regulated kinase 8 | MAPK15 | MK15_HUMAN | Mitogen-activated protein kinase 15
Type:
Serine/threonine-protein kinase
Mol. Mass.:
59850.14
Organism:
Homo sapiens (Human)
Description:
gi_95147356
Residue:
544
Sequence:
MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV
Inhibitor
Name:
BDBM50548060
Synonyms:
CHEMBL4762609
Type:
Small organic molecule
Emp. Form.:
C22H25F2N7O2
Mol. Mass.:
457.4764
SMILES:
Fc1ccc(CC(=O)N2CCC(CC2)Nc2ncc3c(n[nH]c3n2)N2CCOCC2)cc1F
Structure:
