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Target
Ghrelin O-acyltransferase
Ligand
BDBM50548078
Substrate
n/a
Meas. Tech.
ChEMBL_2019861 (CHEMBL4673674)
IC50
0.028000±n/a nM
Citation
 Iyer, MR; Wood, CM; Kunos, G Recent progress in the discovery of ghrelin  RSC Med Chem 11:1136-1144 (2020) [PubMed]  Article 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM50548078
Synonyms:
CHEMBL4746798
Type:
Small organic molecule
Emp. Form.:
C16H12F3N7O
Mol. Mass.:
375.308
SMILES:
Cc1nc2nonc2c(N)c1Cn1ccc(n1)-c1cccc(n1)C(F)(F)F
Structure:
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