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Target
Cathepsin S
Ligand
BDBM50107622
Substrate
n/a
Meas. Tech.
ChEMBL_48670 (CHEMBL658341)
IC50
48±n/a nM
Citation
 Greenspan, PD; Clark, KL; Tommasi, RA; Cowen, SD; McQuire, LW; Farley, DL; van Duzer, JH; Goldberg, RL; Zhou, H; Du, Z; Fitt, JJ; Coppa, DE; Fang, Z; Macchia, W; Zhu, L; Capparelli, MP; Goldstein, R; Wigg, AM; Doughty, JR; Bohacek, RS; Knap, AK Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design. J Med Chem 44:4524-34 (2001) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50107622
Synonyms:
CHEMBL342145 | N-Cyanomethyl-2-diphenylacetylamino-3-phenyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C25H23N3O2
Mol. Mass.:
397.469
SMILES:
O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Structure:
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