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Target
Tyrosine-protein kinase ZAP-70
Ligand
BDBM50546393
Substrate
n/a
Meas. Tech.
ChEMBL_2021867 (CHEMBL4675680)
Kd
73±n/a nM
Citation
 Grimster, NP; Gingipalli, L; Barlaam, B; Su, Q; Zheng, X; Watson, D; Wang, H; Simpson, I; Pike, A; Balazs, A; Boiko, S; Ikeda, TP; Impastato, AC; Jones, NH; Kawatkar, S; Kemmitt, P; Lamont, S; Patel, J; Read, J; Sarkar, U; Sha, L; Tomlinson, RC; Wang, H; Wilson, DM; Zehnder, TE; Wang, L; Wang, P; Goldberg, FW; Shao, W; Fawell, S; Dry, H; Dowling, JE; Edmondson, SD Optimization of a series of potent, selective and orally bioavailable SYK inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ZAP-70
Synonyms:
70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa
Type:
Enzyme
Mol. Mass.:
69881.61
Organism:
Homo sapiens (Human)
Description:
ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column.
Residue:
619
Sequence:
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA
  
Inhibitor
Name:
BDBM50546393
Synonyms:
CHEMBL4751083
Type:
Small organic molecule
Emp. Form.:
C21H25N9O
Mol. Mass.:
419.4829
SMILES:
CNC(=O)c1nn(C)c2ccc(Nc3nccc(n3)-n3cc(CN(C)C)c(C)n3)cc12
Structure:
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