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Target
Tyrosinase
Ligand
BDBM50155411
Substrate
n/a
Meas. Tech.
ChEMBL_2024324 (CHEMBL4678137)
IC50
8840±n/a nM
Citation
 Rosa, GP; Palmeira, A; Resende, DISP; Almeida, IF; Kane-Pagès, A; Barreto, MC; Sousa, E; Pinto, MMM Xanthones for melanogenesis inhibition: Molecular docking and QSAR studies to understand their anti-tyrosinase activity. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50155411
Synonyms:
9-oxoxanthene | 9-xanthenone | 9-xanthone | 9H-xanthen-9-one | CHEMBL186784 | benzophenone oxide | dibenzo-gamma-pyrone | diphenylene ketone oxide | xanthenone | xanthone
Type:
Small organic molecule
Emp. Form.:
C13H8O2
Mol. Mass.:
196.2014
SMILES:
O=c1c2ccccc2oc2ccccc12
Structure:
Search PDB for entries with ligand similarity: