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Target
Proteinase-activated receptor 1
Ligand
BDBM50109076
Substrate
n/a
Meas. Tech.
ChEBML_209247
IC50
360±n/a nM
Citation
 Nantermet, PG; Barrow, JC; Lundell, GF; Pellicore, JM; Rittle, KE; Young, M; Freidinger, RM; Connolly, TM; Condra, C; Karczewski, J; Bednar, RA; Gaul, SL; Gould, RJ; Prendergast, K; Selnick, HG Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1). Bioorg Med Chem Lett 12:319-23 (2002) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50109076
Synonyms:
(3-Azepan-1-yl-propyl)-naphthalen-1-ylmethyl-(3-phenyl-isoxazol-5-yl)-amine | CHEMBL108604
Type:
Small organic molecule
Emp. Form.:
C29H33N3O
Mol. Mass.:
439.5918
SMILES:
C(CN(Cc1cccc2ccccc12)c1cc(no1)-c1ccccc1)CN1CCCCCC1
Structure:
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