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Target
Thromboxane-A synthase
Ligand
BDBM50109126
Substrate
n/a
Meas. Tech.
ChEBML_209933
IC50
21±n/a nM
Citation
 Fujita, M; Seki, T; Inada, H; Shimizu, K; Takahama, A; Sano, T Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs. Bioorg Med Chem Lett 12:341-4 (2002) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50109126
Synonyms:
5-[1-Pyridin-3-yl-1-{4-[(2-pyridin-3-yl-thiazolidine-4-carbonyl)-amino]-phenyl}-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester | CHEMBL116673
Type:
Small organic molecule
Emp. Form.:
C28H31N5O4S
Mol. Mass.:
533.642
SMILES:
CCOC(=O)CCCCO\N=C(/c1ccc(NC(=O)C2CSC(N2)c2cccnc2)cc1)c1cccnc1
Structure:
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