Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50109770
Substrate
n/a
Meas. Tech.
ChEBML_144794
IC50
7800±n/a nM
Citation
 Sato, F; Inoue, Y; Omodani, T; Imano, K; Okazaki, H; Takemura, T; Komiya, M Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase. Bioorg Med Chem Lett 12:551-5 (2002) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50109770
Synonyms:
CHEMBL345509 | {2-Methyl-1-[4-(3-methyl-butoxy)-benzooxazole-2-carbonyl]-propyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C25H30N2O5
Mol. Mass.:
438.5161
SMILES:
CC(C)CCOc1cccc2oc(nc12)C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: