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Target
N-lysine methyltransferase SMYD2
Ligand
BDBM50550528
Substrate
n/a
Meas. Tech.
ChEMBL_2027562 (CHEMBL4681720)
IC50
12±n/a nM
Citation
 Cowen, SD; Russell, D; Dakin, LA; Chen, H; Larsen, NA; Godin, R; Throner, S; Zheng, X; Molina, A; Wu, J; Cheung, T; Howard, T; Garcia-Arenas, R; Keen, N; Pendleton, CS; Pietenpol, JA; Ferguson, AD Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem 59:11079-11097 (2016) [PubMed]  Article 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM50550528
Synonyms:
CHEMBL4756148
Type:
Small organic molecule
Emp. Form.:
C30H34Cl2N4O2
Mol. Mass.:
553.523
SMILES:
Clc1ccc(CCN2CC(C2)Oc2ccccc2-c2cncc(c2)C(=O)NCCCN2CCCC2)cc1Cl
Structure:
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