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Target
Mu-type opioid receptor
Ligand
BDBM50176263
Substrate
n/a
Meas. Tech.
ChEMBL_2030446 (CHEMBL4684604)
EC50
245±n/a nM
Citation
 Huang, H; Wang, W; Xu, X; Zhu, C; Wang, Y; Liu, J; Li, W; Fu, W Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. Eur J Med Chem 189:0 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50176263
Synonyms:
3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol | CHEMBL1400 | O-DESMETHYL TRAMADOL | Ultracet | rel-3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol
Type:
Small organic molecule
Emp. Form.:
C15H23NO2
Mol. Mass.:
249.3486
SMILES:
CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1 |r|
Structure:
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