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Target
Interleukin-6 receptor subunit beta
Ligand
BDBM50552020
Substrate
n/a
Meas. Tech.
ChEMBL_2032954 (CHEMBL4687112)
Kd
3800±n/a nM
Citation
 Song, D; Yu, W; Ren, Y; Zhu, J; Wan, C; Cai, G; Guo, J; Zhang, W; Kong, L Discovery of bazedoxifene analogues targeting glycoprotein 130. Eur J Med Chem 199:0 (2020) [PubMed]  Article 
Target
Name:
Interleukin-6 receptor subunit beta
Synonyms:
CD_antigen=CD130 | CDw130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6R-beta | IL-6RB | IL6RB_HUMAN | IL6ST | Interleukin-6 receptor subunit beta | Interleukin-6 signal transducer | Membrane glycoprotein 130 | Oncostatin-M receptor subunit alpha | gp130
Type:
PROTEIN
Mol. Mass.:
103525.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108130
Residue:
918
Sequence:
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
  
Inhibitor
Name:
BDBM50552020
Synonyms:
CHEMBL4777424
Type:
Small organic molecule
Emp. Form.:
C34H35BrF3N5O2
Mol. Mass.:
682.573
SMILES:
NC(=O)N1N=C(CC1c1cn(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(Br)cc12)c1ccc(cc1)C(F)(F)F |c:4|
Structure:
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