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Target
Glutamate receptor 4
Ligand
BDBM50094024
Substrate
n/a
Meas. Tech.
ChEMBL_72848 (CHEMBL680873)
EC50
290±n/a nM
Citation
 Shepherd, TA; Aikins, JA; Bleakman, D; Cantrell, BE; Rearick, JP; Simon, RL; Smith, EC; Stephenson, GA; Zimmerman, DM; Mandelzys, A; Jarvie, KR; Ho, K; Deverill, M; Kamboj, RK Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors. J Med Chem 45:2101-11 (2002) [PubMed]  Article 
Target
Name:
Glutamate receptor 4
Synonyms:
GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4
Type:
PROTEIN
Mol. Mass.:
100881.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468628
Residue:
902
Sequence:
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
  
Inhibitor
Name:
BDBM50094024
Synonyms:
(+/-) Propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl)-propyl]-amide | CHEMBL435582 | propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl)-propyl]-amide
Type:
Small organic molecule
Emp. Form.:
C19H22N2O2S
Mol. Mass.:
342.455
SMILES:
CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Structure:
Search PDB for entries with ligand similarity: