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Target
Proteasome subunit beta type-8
Ligand
BDBM50554384
Substrate
n/a
Meas. Tech.
ChEMBL_2049561 (CHEMBL4704260)
IC50
2.3±n/a nM
Citation
 Zhan, W; Singh, PK; Ban, Y; Qing, X; Ah Kioon, MD; Fan, H; Zhao, Q; Wang, R; Sukenick, G; Salmon, J; Warren, JD; Ma, X; Barrat, FJ; Nathan, CF; Lin, G Structure-Activity Relationships of Noncovalent Immunoproteasome ?5i-Selective Dipeptides. J Med Chem 63:13103-13123 (2020) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50554384
Synonyms:
CHEMBL4784015
Type:
Small organic molecule
Emp. Form.:
C33H42N4O5
Mol. Mass.:
574.7104
SMILES:
COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r|
Structure:
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