Reaction Details Report a problem with these data
Target
Histone deacetylase 2b
Ligand
BDBM50115659
Substrate
n/a
Meas. Tech.
ChEMBL_87872 (CHEMBL697294)
IC50
210±n/a nM
Citation
 Wittich, S; Scherf, H; Xie, C; Brosch, G; Loidl, P; Gerhäuser, C; Jung, M Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem 45:3296-309 (2002) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50115659
Synonyms:
(S)-3-biphenyl-4-yl-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | 3-Biphenyl-4-yl-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | CHEMBL113003
Type:
Small organic molecule
Emp. Form.:
C24H30N2O5
Mol. Mass.:
426.5054
SMILES:
COC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCCCCCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: