Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50115950
Substrate
n/a
Meas. Tech.
ChEBML_48969
IC50
1100±n/a nM
Citation
 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification. Bioorg Med Chem Lett 12:2043-6 (2002) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50115950
Synonyms:
4-[(E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoylamino]-2'-sulfamoyl-biphenyl-3-carboxylic acid amide | CHEMBL65091
Type:
Small organic molecule
Emp. Form.:
C26H22FN5O4S
Mol. Mass.:
519.547
SMILES:
C\C(=C(/F)C(=O)Nc1ccc(cc1C(N)=O)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1
Structure:
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