Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50116107
Substrate
n/a
Meas. Tech.
ChEBML_51124
Ki
25±n/a nM
Citation
 Yuan, J; Gulianello, M; De Lombaert, S; Brodbeck, R; Kieltyka, A; Hodgetts, KJ 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett 12:2133-6 (2002) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50116107
Synonyms:
Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-amine | CHEMBL302589
Type:
Small organic molecule
Emp. Form.:
C17H19Cl2N5
Mol. Mass.:
364.272
SMILES:
CCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 |(-3.92,4.22,;-3.92,2.68,;-2.58,1.91,;-2.58,.37,;-1.25,-.4,;-1.24,-1.94,;-2.57,-2.71,;-2.57,-4.25,;-3.91,-5.02,;-1.24,-5.02,;.1,-4.25,;1.57,-4.74,;2.05,-6.21,;1.01,-7.33,;1.49,-8.8,;2.99,-9.13,;3.48,-10.59,;4.02,-7.96,;3.55,-6.52,;4.56,-5.37,;2.48,-3.48,;4.02,-3.48,;1.57,-2.22,;.1,-2.71,)|
Structure:
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