Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50116121
Substrate
n/a
Meas. Tech.
ChEBML_51124
Ki
17±n/a nM
Citation
 Yuan, J; Gulianello, M; De Lombaert, S; Brodbeck, R; Kieltyka, A; Hodgetts, KJ 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett 12:2133-6 (2002) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50116121
Synonyms:
CHEMBL69968 | Cyclopentyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-amine
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2N5
Mol. Mass.:
376.283
SMILES:
Cc1nc(NC2CCCC2)c2nn(C)c(-c3ccc(Cl)cc3Cl)c2n1 |(-4.96,-7.33,;-3.63,-6.56,;-3.63,-5.01,;-2.3,-4.24,;-2.3,-2.7,;-3.63,-1.94,;-5.03,-2.56,;-6.06,-1.42,;-5.31,-.09,;-3.79,-.4,;-.96,-5.01,;.51,-4.53,;1.43,-5.78,;2.97,-5.78,;.51,-7.04,;.99,-8.49,;-.04,-9.63,;.43,-11.1,;1.94,-11.42,;2.41,-12.87,;2.97,-10.26,;2.49,-8.81,;3.5,-7.65,;-.96,-6.56,;-2.3,-7.33,)|
Structure:
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