Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50116122
Substrate
n/a
Meas. Tech.
ChEBML_51124
Ki
145±n/a nM
Citation
 Yuan, J; Gulianello, M; De Lombaert, S; Brodbeck, R; Kieltyka, A; Hodgetts, KJ 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett 12:2133-6 (2002) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50116122
Synonyms:
CHEMBL303639 | N-[3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-N',N'-dimethyl-N-propyl-ethane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C20H26Cl2N6
Mol. Mass.:
421.367
SMILES:
CCCN(CCN(C)C)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 |(-5.89,-.5,;-4.56,-1.26,;-3.22,-.49,;-1.89,-1.24,;-.55,-.47,;.78,-1.24,;2.11,-.47,;3.44,-1.24,;2.11,1.07,;-1.88,-2.78,;-3.21,-3.57,;-3.21,-5.11,;-4.55,-5.88,;-1.88,-5.88,;-.55,-5.11,;.92,-5.58,;1.41,-7.05,;.37,-8.17,;.85,-9.66,;2.36,-9.97,;2.83,-11.44,;3.38,-8.82,;2.9,-7.36,;3.93,-6.21,;1.84,-4.32,;3.38,-4.32,;.92,-3.08,;-.55,-3.55,)|
Structure:
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