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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50116948
Substrate
n/a
Meas. Tech.
ChEBML_3696
Ki
109±n/a nM
Citation
 Isaac, MB; Xin, T; O'Brien, A; St-Martin, D; Naismith, A; MacLean, N; Wilson, J; Demchyshyn, L; Tehim, A; Slassi, A 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands. Bioorg Med Chem Lett 12:2451-4 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50116948
Synonyms:
1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-vinyl-1H-indole | CHEMBL81576
Type:
Small organic molecule
Emp. Form.:
C18H25N3
Mol. Mass.:
283.4112
SMILES:
CN1CCCN(CCn2ccc3ccc(C=C)cc23)CC1
Structure:
Search PDB for entries with ligand similarity: