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Target
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Ligand
BDBM31712
Substrate
n/a
Meas. Tech.
ChEMBL_2057749 (CHEMBL4712750)
IC50
1600±n/a nM
Citation
 Mock, ED; Kotsogianni, I; Driever, WPF; Fonseca, CS; Vooijs, JM; den Dulk, H; van Boeckel, CAA; van der Stelt, M Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of  J Med Chem 64:481-515 (2021) [PubMed]  Article 
Target
Name:
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Synonyms:
3.1.4.54 | C7orf18 | N-acyl phosphatidylethanolamine phospholipase D | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | NAPE-PLD | NAPE-hydrolyzing phospholipase D | NAPEPLD | NAPEP_HUMAN
Type:
PROTEIN
Mol. Mass.:
45590.93
Organism:
Homo sapiens
Description:
ChEMBL_119932
Residue:
393
Sequence:
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAEDFFVLKHGESRYLNNDDENF
  
Inhibitor
Name:
BDBM31712
Synonyms:
HEXACHLOROPHENE | Hexach-lorophene | MLS000028433 | SMR000058356 | cid_3598
Type:
Small organic molecule
Emp. Form.:
C13H6Cl6O2
Mol. Mass.:
406.904
SMILES:
Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl
Structure:
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