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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50120126
Substrate
n/a
Meas. Tech.
ChEBML_96910
IC50
9±n/a nM
Citation
 Chen, P; Iwanowicz, EJ; Norris, D; Gu, HH; Lin, J; Moquin, RV; Das, J; Wityak, J; Spergel, SH; de Fex, H; Pang, S; Pitt, S; Shen, DR; Schieven, GL; Barrish, JC Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency. Bioorg Med Chem Lett 12:3153-6 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50120126
Synonyms:
(2-Chloro-6-methyl-phenyl)-[8-(4-methyl-[1,4]diazepan-1-yl)-imidazo[1,5-a]quinoxalin-4-yl]-amine | CHEMBL110783 | N-(2-chloro-6-methylphenyl)-8-(4-methyl-1,4-diazepan-1-yl)imidazo[1,5-a]quinoxalin-4-amine
Type:
Small organic molecule
Emp. Form.:
C23H25ClN6
Mol. Mass.:
420.938
SMILES:
CN1CCCN(CC1)c1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2c1
Structure:
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