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Target
Probable G-protein coupled receptor 142
Ligand
BDBM50558168
Substrate
n/a
Meas. Tech.
ChEMBL_2062194 (CHEMBL4717447)
IC50
63±n/a nM
Citation
 Wilson, JE; Kurukulasuriya, R; Sinz, C; Lombardo, M; Bender, K; Parker, D; Sherer, EC; Costa, M; Dingley, K; Li, X; Mitelman, S; Tong, S; Bugianesi, R; Ehrhardt, A; Priest, B; Ratliff, K; Ujjainwalla, F; Nargund, R; Hagmann, WK; Edmondson, S Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26:2947-2951 (2016) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM50558168
Synonyms:
CHEMBL4755454
Type:
Small organic molecule
Emp. Form.:
C22H16F3N5O2
Mol. Mass.:
439.3899
SMILES:
FC(F)(F)Oc1cccc(Nc2nnc3-c4cc(ccc4OCCn23)-c2ccncc2)c1
Structure:
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