Reaction Details Report a problem with these data
Target
Probable G-protein coupled receptor 142
Ligand
BDBM50558178
Substrate
n/a
Meas. Tech.
ChEMBL_2062195 (CHEMBL4717448)
IC50
486±n/a nM
Citation
 Wilson, JE; Kurukulasuriya, R; Sinz, C; Lombardo, M; Bender, K; Parker, D; Sherer, EC; Costa, M; Dingley, K; Li, X; Mitelman, S; Tong, S; Bugianesi, R; Ehrhardt, A; Priest, B; Ratliff, K; Ujjainwalla, F; Nargund, R; Hagmann, WK; Edmondson, S Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26:2947-2951 (2016) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
GP142_MOUSE | Gpr142
Type:
PROTEIN
Mol. Mass.:
40779.27
Organism:
Mus musculus
Description:
ChEMBL_985965
Residue:
365
Sequence:
MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
  
Inhibitor
Name:
BDBM50558178
Synonyms:
CHEMBL4750165
Type:
Small organic molecule
Emp. Form.:
C23H23N3O4
Mol. Mass.:
405.4464
SMILES:
COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2OC)c1
Structure:
Search PDB for entries with ligand similarity: