Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50121031
Substrate
n/a
Meas. Tech.
ChEBML_48517
IC50
600±n/a nM
Citation
Zhou, NE; Guo, D; Kaleta, J; Purisima, E; Menard, R; Micetich, RG; Singh, R Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors. Bioorg Med Chem Lett 12:3413-5 (2002) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_RAT | Cathepsin L | Ctsl | Ctsl1
Type:
PROTEIN
Mol. Mass.:
37662.10
Organism:
Rattus norvegicus
Description:
ChEMBL_48517
Residue:
334
Sequence:
MTPLLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIVN
Inhibitor
Name:
BDBM50121031
Synonyms:
CHEMBL419772 | [(S)-2-Methyl-1-((5R,6S)-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-propyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C18H23N3O5
Mol. Mass.:
361.3923
SMILES:
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H]1[C@H]2OCCN2C1=O