Target
Glucagon receptor
Ligand
BDBM50121046
Substrate
n/a
Meas. Tech.
ChEMBL_72863 (CHEMBL683959)
IC50
25±n/a nM
Citation
 Ladouceur, GHCook, JHHertzog, DLJones, JHHundertmark, TKorpusik, MLease, TGLivingston, JNMacDougall, MLOsterhout, MHPhelan, KRomero, RHSchoen, WRShao, CSmith, RA Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorg Med Chem Lett 12:3421-4 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50121046
Synonyms:
2-[3-(1-Hydroxy-ethyl)-2,6-diisopropyl-5-propyl-pyridin-4-yl]-phenol | CHEMBL116413
Type:
Small organic molecule
Emp. Form.:
C22H31NO2
Mol. Mass.:
341.487
SMILES:
CCCc1c(nc(C(C)C)c(C(C)O)c1-c1ccccc1O)C(C)C |(2.39,-.22,;1.05,-.99,;-.28,-.22,;-1.6,-.98,;-1.6,-2.53,;-2.94,-3.3,;-4.27,-2.53,;-5.62,-3.3,;-5.62,-4.84,;-6.95,-2.53,;-4.27,-.98,;-5.6,-.22,;-6.95,-.99,;-5.6,1.32,;-2.94,-.21,;-2.96,1.33,;-4.27,2.1,;-4.29,3.62,;-2.96,4.4,;-1.63,3.63,;-1.63,2.09,;-.28,1.32,;-.27,-3.3,;1.06,-2.52,;-.27,-4.84,)|
Structure:
Search PDB for entries with ligand similarity: