Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50121045
Substrate
n/a
Meas. Tech.
ChEMBL_72859 (CHEMBL878574)
IC50
20±n/a nM
Citation
 Ladouceur, GH; Cook, JH; Hertzog, DL; Jones, JH; Hundertmark, T; Korpusik, M; Lease, TG; Livingston, JN; MacDougall, ML; Osterhout, MH; Phelan, K; Romero, RH; Schoen, WR; Shao, C; Smith, RA Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorg Med Chem Lett 12:3421-4 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50121045
Synonyms:
2-[3-Ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol | CHEMBL114762
Type:
Small organic molecule
Emp. Form.:
C21H28FNO2
Mol. Mass.:
345.4509
SMILES:
CCc1c(nc(C(C)C)c(C(C)O)c1-c1ccc(F)cc1O)C(C)C |(1.05,-.99,;-.28,-.22,;-1.6,-.98,;-1.6,-2.53,;-2.94,-3.3,;-4.27,-2.53,;-5.62,-3.3,;-6.95,-2.53,;-5.62,-4.84,;-4.27,-.98,;-5.6,-.22,;-6.95,-.99,;-5.6,1.32,;-2.94,-.21,;-2.96,1.33,;-4.27,2.1,;-4.29,3.62,;-2.96,4.4,;-2.96,5.94,;-1.63,3.63,;-1.63,2.09,;-.28,1.32,;-.27,-3.3,;-.27,-4.84,;1.06,-2.52,)|
Structure:
Search PDB for entries with ligand similarity: