Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50109322
Substrate
n/a
Meas. Tech.
ChEBML_72859
IC50
7000±n/a nM
Citation
Ladouceur, GH; Cook, JH; Hertzog, DL; Jones, JH; Hundertmark, T; Korpusik, M; Lease, TG; Livingston, JN; MacDougall, ML; Osterhout, MH; Phelan, K; Romero, RH; Schoen, WR; Shao, C; Smith, RA Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorg Med Chem Lett 12:3421-4 (2002) [PubMed] Article
More Info.:
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
Inhibitor
Name:
BDBM50109322
Synonyms:
CHEMBL114761 | [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-(2-methyl-propenyl)-pyridin-3-yl]-methanol
Type:
Small organic molecule
Emp. Form.:
C22H28FNO
Mol. Mass.:
341.4622
SMILES:
[#6]-[#6](-[#6])-c1nc(-[#6](-[#6])-[#6])c(\[#6]=[#6](\[#6])-[#6])c(-c2ccc(F)cc2)c1-[#6]-[#8]