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Target
Glucagon receptor
Ligand
BDBM50112476
Substrate
n/a
Meas. Tech.
ChEBML_72859
IC50
190±n/a nM
Citation
 Ladouceur, GH; Cook, JH; Hertzog, DL; Jones, JH; Hundertmark, T; Korpusik, M; Lease, TG; Livingston, JN; MacDougall, ML; Osterhout, MH; Phelan, K; Romero, RH; Schoen, WR; Shao, C; Smith, RA Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorg Med Chem Lett 12:3421-4 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50112476
Synonyms:
5-Fluoro-2-(3-hydroxymethyl-2,6-diisopropyl-5-pentyl-pyridin-4-yl)-phenol | CHEMBL24388
Type:
Small organic molecule
Emp. Form.:
C23H32FNO2
Mol. Mass.:
373.5041
SMILES:
CCCCCc1c(nc(C(C)C)c(CO)c1-c1ccc(F)cc1O)C(C)C |(13.61,-8.26,;12.28,-9.04,;10.94,-8.27,;9.62,-9.05,;8.27,-8.31,;6.95,-9.08,;6.95,-10.62,;5.61,-11.39,;4.28,-10.62,;2.95,-11.39,;2.95,-12.93,;1.62,-10.62,;4.28,-9.08,;2.95,-8.31,;1.62,-9.08,;5.61,-8.29,;5.61,-6.77,;4.28,-6,;4.25,-4.48,;5.6,-3.69,;5.58,-2.15,;6.94,-4.46,;6.93,-6,;8.27,-6.77,;8.29,-11.39,;9.62,-10.59,;8.29,-12.93,)|
Structure:
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