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Target
Calcium/calmodulin-dependent protein kinase type 1
Ligand
BDBM50558812
Substrate
n/a
Meas. Tech.
ChEMBL_2064976 (CHEMBL4720229)
IC50
>10000±n/a nM
Citation
 He, L; Pei, H; Zhang, C; Shao, M; Li, D; Tang, M; Wang, T; Chen, X; Xiang, M; Chen, L Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis. Eur J Med Chem 145:96-112 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type 1
Synonyms:
CAMK1 | CaM kinase I | CaM kinase I alpha | CaM-KI | CaMKI-alpha | Calcium/calmodulin-dependent protein kinase type 1 | KCC1A_HUMAN
Type:
PROTEIN
Mol. Mass.:
41325.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655701
Residue:
370
Sequence:
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL
  
Inhibitor
Name:
BDBM50558812
Synonyms:
CHEMBL4755698
Type:
Small organic molecule
Emp. Form.:
C22H23N5O3
Mol. Mass.:
405.4497
SMILES:
Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc4OCOc4c3)c12
Structure:
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