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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50121085
Substrate
n/a
Meas. Tech.
ChEBML_71598
Ki
51±n/a nM
Citation
 Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett 12:3467-70 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50121085
Synonyms:
4-({[5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carbonyl]-amino}-methyl)-cyclohexanecarboxylic acid ethyl ester | CHEMBL325843
Type:
Small organic molecule
Emp. Form.:
C31H43NO4
Mol. Mass.:
493.6774
SMILES:
CCOC(=O)[C@H]1CC[C@H](CNC(=O)c2ccc(Cc3cc4c(cc3C)C(C)(C)CCC4(C)C)o2)CC1 |wU:5.4,wD:8.8,(.17,.16,;.66,1.61,;-.35,2.77,;.14,4.22,;-.88,5.37,;1.66,4.53,;2.15,6,;3.66,6.29,;4.67,5.13,;6.18,5.41,;7.19,4.26,;6.7,2.82,;5.19,2.51,;7.71,1.65,;9.25,1.79,;9.87,.41,;8.71,-.64,;8.71,-2.18,;7.36,-2.95,;6.03,-2.18,;4.7,-2.95,;4.7,-4.49,;6.03,-5.26,;7.36,-4.49,;8.71,-5.27,;3.37,-5.26,;4.46,-6.35,;1.87,-5.65,;2.03,-4.49,;2.03,-2.95,;3.37,-2.18,;4.7,-1.41,;2.03,-1.41,;7.38,.13,;4.16,3.66,;2.66,3.38,)|
Structure:
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