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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50121086
Substrate
n/a
Meas. Tech.
ChEBML_71598
Ki
42±n/a nM
Citation
 Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett 12:3467-70 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50121086
Synonyms:
5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid (4-aminomethyl-cyclohexylmethyl)-amide | CHEMBL115425
Type:
Small organic molecule
Emp. Form.:
C29H42N2O2
Mol. Mass.:
450.656
SMILES:
Cc1cc2c(cc1Cc1ccc(o1)C(=O)NCC1CCC(CN)CC1)C(C)(C)CCC2(C)C |(-.7,-11.61,;-2.04,-10.83,;-3.38,-11.6,;-4.71,-10.83,;-4.71,-9.3,;-3.38,-8.53,;-2.04,-9.3,;-.7,-8.53,;-.69,-6.99,;.45,-5.95,;-.16,-4.57,;-1.69,-4.71,;-2.02,-6.22,;-2.72,-3.55,;-4.22,-3.85,;-2.21,-2.1,;-3.23,-.94,;-4.73,-1.24,;-5.23,-2.69,;-6.75,-2.99,;-7.75,-1.83,;-9.27,-2.14,;-10.29,-1,;-7.26,-.36,;-5.75,-.08,;-6.03,-8.53,;-7.38,-7.76,;-4.7,-7.76,;-7.38,-9.3,;-7.38,-10.83,;-6.03,-11.6,;-7.53,-12.01,;-4.94,-12.68,)|
Structure:
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