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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50121084
Substrate
n/a
Meas. Tech.
ChEBML_71598
Ki
180±n/a nM
Citation
 Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett 12:3467-70 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50121084
Synonyms:
5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid (4-{[(3,5-dimethyl-isoxazol-4-ylmethyl)-amino]-methyl}-cyclohexylmethyl)-amide | CHEMBL324394
Type:
Small organic molecule
Emp. Form.:
C35H49N3O3
Mol. Mass.:
559.7819
SMILES:
Cc1noc(C)c1CNCC1CCC(CNC(=O)c2ccc(Cc3cc4c(cc3C)C(C)(C)CCC4(C)C)o2)CC1 |(2.34,1.95,;3.11,3.28,;2.5,4.71,;3.65,5.72,;4.98,4.94,;6.39,5.55,;4.64,3.43,;5.65,2.28,;5.18,.82,;6.21,-.33,;7.72,-.03,;8.73,-1.19,;10.23,-.89,;10.74,.56,;12.25,.86,;13.26,-.29,;12.76,-1.75,;11.25,-2.05,;13.77,-2.92,;15.31,-2.76,;15.94,-4.15,;14.78,-5.19,;14.78,-6.73,;13.42,-7.5,;12.09,-6.73,;10.76,-7.5,;10.76,-9.04,;12.09,-9.81,;13.42,-9.04,;14.78,-9.83,;9.43,-9.81,;10.53,-10.9,;7.94,-10.22,;8.08,-9.04,;8.08,-7.5,;9.43,-6.73,;8.08,-5.96,;10.76,-5.96,;13.45,-4.42,;9.73,1.73,;8.31,1.56,)|
Structure:
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