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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50121189
Substrate
n/a
Meas. Tech.
ChEBML_71590
Ki
92±n/a nM
Citation
 Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Connors, PJ; Struthers, RS; Reinhart, GJ; Wang, X; Saunders, J; Chen, C A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists. Bioorg Med Chem Lett 12:3491-5 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50121189
Synonyms:
8-Fluoro-1-(2-fluoro-benzyl)-6-[(furan-2-ylmethyl-methyl-amino)-methyl]-7-(4-isobutoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester | CHEMBL117346
Type:
Small organic molecule
Emp. Form.:
C34H35F2N3O5
Mol. Mass.:
603.6556
SMILES:
CCOC(=O)c1cn(Cc2ccccc2F)c2c(F)c(c(CN(C)Cc3ccco3)n2c1=O)-c1ccc(OCC(C)C)cc1
Structure:
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