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Target
Homeodomain-interacting protein kinase 4
Ligand
BDBM50559221
Substrate
n/a
Meas. Tech.
ChEMBL_2068509 (CHEMBL4723762)
Kd
290±n/a nM
Citation
 Picado, A; Chaikuad, A; Wells, CI; Shrestha, S; Zuercher, WJ; Pickett, JE; Kwarcinski, FE; Sinha, P; de Silva, CS; Zutshi, R; Liu, S; Kannan, N; Knapp, S; Drewry, DH; Willson, TM A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem 63:14626-14646 (2020) [PubMed]  Article 
Target
Name:
Homeodomain-interacting protein kinase 4
Synonyms:
HIPK4 | HIPK4_HUMAN
Type:
PROTEIN
Mol. Mass.:
69426.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655821
Residue:
616
Sequence:
MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH
  
Inhibitor
Name:
BDBM50559221
Synonyms:
CHEMBL4763392
Type:
Small organic molecule
Emp. Form.:
C16H10N2O2S3
Mol. Mass.:
358.458
SMILES:
OC(=O)CSc1ncnc2sc(cc12)-c1cc2ccccc2s1
Structure:
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