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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50121688
Substrate
n/a
Meas. Tech.
ChEBML_123597
IC50
0.014000±n/a nM
Citation
 Ooms, F; Frédérick, R; Durant, F; Petzer, JP; Castagnoli, N; Van der Schyf, CJ; Wouters, J Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative. Bioorg Med Chem Lett 13:69-73 (2002) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50121688
Synonyms:
3-Methyl-8-(4,4,4-trifluoro-butoxy)-indeno[1,2-c]pyridazin-5-one | 3-methyl-8-[4,4,4-trifluorobutoxy]-5H-indeno[1,2-c]pyridazin-5-one | CHEMBL348961
Type:
Small organic molecule
Emp. Form.:
C16H13F3N2O2
Mol. Mass.:
322.2818
SMILES:
Cc1cc2C(=O)c3ccc(OCCCC(F)(F)F)cc3-c2nn1
Structure:
Search PDB for entries with ligand similarity: